In each edition, I’ll share the most interesting and actionable findings from the latest health studies so you can stay informed (without sifting through dense medical journals).
Here’s what I found this month:
Butyrate Eases Joint Pain—and May Work Through the Gut
Researchers gave 112 people with knee osteoarthritis either 300 mg of butyrate or a placebo daily for three months in a recent 2025 study. Those taking butyrate saw meaningful improvements in knee function, along with reduced pain and stiffness. Blood tests also showed lower markers of inflammation and gut permeability, suggesting that butyrate may support joint health by improving gut health first.
Probiotics Improve Mood, Sleep, and Gut Health in People with Depression
A 2025 study followed 86 people with major depression and compared them to healthy individuals. Participants took either a multi-strain probiotic or a placebo. Those who took the probiotic had better vagus nerve activity (which plays a key role in mood regulation), slept better, and showed more of a beneficial gut bacteria called Akkermansia muciniphila. The researchers suggest that using probiotics for longer than three months may be needed to see full benefits—similar to how they help in conditions like IBS.
This Traditional Herb Eases Post-COVID Fatigue
Astragalus, an herb used in traditional Chinese medicine for energy and immune support, was tested in a study from this year involving 64 people with long-term fatigue after COVID-19. One group took 1,000 mg of astragalus daily, while the other got a placebo. After one month, the astragalus group reported an 83% reduction in fatigue—compared to just 28% in the placebo group. This suggests astragalus may offer real support for post-viral fatigue recovery.
Curcumin May Help Ease Endometriosis Pain
A study of 86 women with endometriosis tested whether adding curcumin to their standard hormone therapy could make a difference. After two months, those taking curcumin reported less menstrual cramping and pelvic pain (including pain during bowel movements and sex), along with a better quality of life and improved sexual function.
Stay tuned for more fascinating insights in the next edition of the Ruscio Research Report!
In Health,
Dr. Michael Ruscio, DC
Adjunct Professor, University of Bridgeport Clinical Researcher
