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27 April, 2026
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top stories
1. Revolution Medicines threatens to sue Erasca in showdown over closely watched RAS drugs
2. Sun Pharma to buy Organon for $11.75B in major portfolio expansion
3. Lilly announces a new cancer deal, paying Ajax up to $2.3B for JAK inhibitor
4.
news briefing
Thermo Fisher sells microbiology biz; Ligand to buy XOMA
5. Q&A: Intellia CEO talks first Phase 3 CRISPR readout and what’s next
6. Veradermics wins at growing hair with oral Rogaine in late-stage trial
more stories
 
Lydia Ramsey Pflanzer
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The Endpoints News team is gearing up for a week of earnings coverage, with Novartis tomorrow; GSK, AstraZeneca and AbbVie on Wednesday; and Lilly and Merck on Thursday. Moderna finishes up the week on Friday. I'm looking out for some more color on what's going on with the Foundayo launch, and why prescriptions for the first two weeks are trending lower than expected.

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Lydia Ramsey Pflanzer
Deputy Editor, Endpoints News
Erasca headquarters in San Diego, CA (Shutterstock)
1
by Max Bayer

Ear­li­er this month, a new can­cer drug cap­ti­vat­ed pa­tients and in­vestors.

Now the lawyers get their turn.

On Mon­day, the biotech Eras­ca said it had re­ceived a le­gal threat from Rev­o­lu­tion Med­i­ci­nes' lawyers over its can­cer drug ERAS-0015, which is be­ing test­ed in sol­id tu­mors — and which will re­port out high­ly an­tic­i­pat­ed da­ta lat­er on Mon­day. Rev­o­lu­tion's drug darax­on­ra­sib has shown ex­cit­ing re­sults in hard-to-treat pan­cre­at­ic can­cer. Both drugs tar­get RAS, a path­way in­volved in can­cer that has been no­to­ri­ous­ly dif­fi­cult to at­tack.

Ac­cord­ing to a se­cu­ri­ties fil­ing from Eras­ca on Mon­day, Rev­o­lu­tion is al­leg­ing that Eras­ca's drug is "sub­stan­tial­ly equiv­a­lent" to Rev­o­lu­tion's drug, in­fring­ing on its patents, and that its trade se­crets have been vi­o­lat­ed. Lawyers for Rev­o­lu­tion al­so took is­sue with how Eras­ca has com­pared pre­clin­i­cal da­ta for ERAS-0015 to darax­on­ra­sib, ac­cord­ing to the fil­ing.

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2
by Kyle LaHucik

In­di­an drug gi­ant Sun Phar­ma has lined up an $11.75 bil­lion ac­qui­si­tion of Organon, a women’s health and biosim­i­lar mak­er spun out of Mer­ck in 2021.

The all-cash deal came in at $14 per share OGN and is slat­ed to close ear­ly next year, the com­pa­nies said Sun­day evening.

At near­ly $12 bil­lion, it marks the largest phar­ma M&A deal of 2026 so far and one of the biggest drug­mak­er trans­ac­tions in re­cent years. The merg­er adds to the blis­ter­ing pace of bio­phar­ma M&A over the past two quar­ters as drug­mak­ers fill their pipelines.

Sun Phar­ma gains ac­cess to a suite of brand­ed prod­ucts, gener­ics and biosim­i­lars. The move po­si­tions it as one of the top three com­pa­nies in glob­al women’s health, Sun Phar­ma said. It will al­so fur­ther push the com­pa­ny up the list of top glob­al phar­ma­ceu­ti­cal mak­ers by rev­enue.

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3
by Kyle LaHucik

Eli Lil­ly keeps putting its GLP-1 wind­fall to use.

On Mon­day, the an­ti-obe­si­ty drug­mak­er an­nounced its lat­est deal to ex­pand its pipeline of fu­ture drugs, say­ing it would spend as much as $2.3 bil­lion on Ajax Ther­a­peu­tics and its clin­i­cal-stage JAK2 work in blood can­cer. Lil­ly and Ajax did­n't dis­close how much of that is in cash, and how much is in fu­ture re­sults-based in­cen­tive pay­outs.

The first test of that bet is like­ly to come lat­er this year, when Ajax's lead drug, AJ1-11095, will re­port proof-of-con­cept da­ta from a Phase 1 tri­al in the rare blood can­cer known as myelofi­bro­sis.

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US Pharma and Biotech Summit - May 14, 2026
US biopharma still leads the world in high-risk drug development, but the road from innovation to access has never been harder to predict. Hear from top executives and investors on how they’re navigating what’s next. Join us.
News Briefing: Quick hits from the biopharma web
4
by ENDPOINTS

Ther­mo Fish­er Sci­en­tif­ic sells mi­cro­bi­ol­o­gy busi­ness: As­torg, a Eu­ro­pean pri­vate eq­ui­ty firm, will ac­quire the unit for $1.075 bil­lion. Ther­mo Fish­er’s mi­cro­bi­ol­o­gy busi­ness is part of its spe­cial­ty di­ag­nos­tics seg­ment, and fo­cus­es on an­timi­cro­bial sus­cep­ti­bil­i­ty test­ing and oth­er cul­ture work for both phar­ma and food safe­ty test­ing. Ther­mo Fish­er ex­pects the deal to close in the sec­ond half of this year. The an­nounce­ment was light on de­tails, with CEO Marc Casper say­ing the deal “pro­vides ad­di­tion­al cap­i­tal we can de­ploy to cre­ate share­hold­er val­ue.” The com­pa­ny has dis­closed mul­ti­ple rounds of lay­offs this year, as it phas­es out a lab­o­ra­to­ry prod­ucts fac­to­ry in North Car­oli­na and clos­es a chem­i­cal analy­sis man­u­fac­tur­ing site in Mass­a­chu­setts. — Nicole De­Feud­is

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John Leonard, Intellia CEO
5
by Lei Lei Wu, Ryan Cross

In­tel­lia Ther­a­peu­tics re­port­ed this morn­ing on the Phase 3 suc­cess of a gene edit­ing treat­ment for hered­i­tary an­gioede­ma, a dis­ease that caus­es un­pre­dictable, dis­fig­ur­ing and po­ten­tial­ly dan­ger­ous swelling at­tacks. The biotech aims to have its gene edit­ing ther­a­py — the first of its kind to reach this stage — on the mar­ket next year.

In­tel­lia CEO John Leonard spoke with End­points News ahead of the read­out to talk about the find­ings, and what the mile­stone means for a gene edit­ing in­dus­try that has fall­en out of fa­vor re­cent­ly. The fol­low­ing in­ter­view has been edit­ed sub­stan­tial­ly for length and clar­i­ty.

End­points: Where were you when you got the news?

Leonard: I was in a room at In­tel­lia, and our gen­er­al man­ag­er shared the re&s