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Design Therapeutics' promising early data in Friedreich ataxia Read in browser
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1. After key trial fail, Regeneron reaches $125M Parabilis deal for hard-to-catch drug targets
2. Merck's ADC sac-TMT gets its first global Phase 3 win ahead of schedule
3.
news briefing
Design Therapeutics' Friedreich ataxia data; Vincentage's obesity results from China
4. Regeneron's Phase 3 skin cancer miss adds to mounting failures in LAG-3
5. AstraZeneca's blood pressure pill approved, but competition could be around the corner
6. Candel reports prostate cancer drug's long-term data ahead of FDA filing
7. Are pharma megadeals dead? Smaller targets take priority amid hunt for blockbusters
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Karen Weintraub
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Merck and China-based Kelun-Biotech scored a Phase 3 victory with their experimental antibody-drug conjugate in advanced endometrial cancer, Max Gelman reports. Meanwhile, Lei Lei Wu unpacks a new up-to-$2.2 billion deal between Regeneron and Parabilis Medicines, for the smaller company’s swings at formerly “undruggable” cancer targets.

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Karen Weintraub
Deputy Editor, Endpoints News
Mathai Mammen, Parabilis Medicines CEO (via FogPharma)
1
by Lei Lei Wu

As Re­gen­eron’s can­cer port­fo­lio con­tin­ues to suf­fer set­backs, the com­pa­ny is plac­ing a bet in a dif­fer­ent di­rec­tion through a deal with Para­bilis Med­i­cines val­ued...

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2
by Max Gelman

An ex­per­i­men­tal an­ti­body-drug con­ju­gate from Mer­ck and Chi­na-based Kelun-Biotech suc­ceed­ed in a glob­al Phase 3 study for the first time, giv­ing Mer­ck a key pipeline...

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News Briefing: Quick hits from the biopharma web
3
by ENDPOINTS

Plus, news about En­her­tu and Tecen­triq.

💪 De­sign Ther­a­peu­tics shares Phase 1/2 da­ta in Friedre­ich atax­ia: The Cal­i­for­nia biotech’s DT-216P2 giv­en at 1 mg/kg led...

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LGBTQ+ LEADERSHIP IN 2026
LGBTQ+ diversity drives innovation in biopharma — but transgender and non-binary professionals face rising challenges. Endpoints is going live with our fourth annual special report celebrating the honorees giving voice and visibility while forging ahead across life sciences. Join us.
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by Ayisha Sharma

Re­gen­eron Phar­ma­ceu­ti­cals’ LAG-3 in­hibitor called fi­an­limab has flunked a late-stage skin can­cer tri­al, mark­ing yet an­oth­er blow for the drug class.

The an­nounce­ment fol­lows a...

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