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The Cut
 

May 21, 2026

 

HEALTH

‘It’s Like Magic’ Many women say a cocktail of anti-histamines and Pepcid AC improves their perimenopause and PMDD symptoms. Why?

By Katie Heaney

Animation: The Cut; Photo/Video: Getty

Before perimenopause, Angela hiked over 100 miles a month. “I was incredibly active,” she told me. “I moved to the mountains so I could hike.” Then: “Man, oh man,” she says with a sigh. “Perimenopause wiped me out.”

With approval from her doctor, Angela began taking HRT, or hormone replacement therapy, for her symptoms, but it didn’t make a big enough dent. She was still fatigued and, worse, almost completely uninterested in her former hobbies, hiking included. Then, a few months ago, Angela saw a social-media post from a woman who took daily anti-histamines (like Allegra, Claritin, or Zyrtec) plus Pepcid AC (a common antacid) for her perimenopause symptoms. Her results, as reported, sounded miraculous: no more brain fog, no more tossing and turning all night. Even her mood vastly improved.

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Celebrity News

Gossip, revelations, and timelines.

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Today’s Top Stories

Personal-finance columnist Charlotte Cowles responds to a reader who wants to make sure her prenup with her fiancé is fair. 

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In Widow’s Bay, Matthew Rhys plays the mayor of the most mysterious island TV has seen since Lost.

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Tennis champion Maria Sharapova talks discipline after retirement, building her podcast, Pretty Tough, and the small wins that still keep her moving.

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