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A treat­ment in search of a dis­ease – Leg­is­la­tion un­nec­es­sar­i­ly threat­ens Cal­i­for­nia’s lead­er­ship in life sci­ences
top stories
1. Skyrizi's momentum defies J&J's rival Icotyde as AbbVie raises full-year sales guidance
2. Moderna delays norovirus vaccine trial readout because of too few infections
3. Pharma groups back changes to 340B rebate pilot as earlier version remains stuck in court
4. Novo Nordisk rocked by late-stage cardiovascular drug failure
5. Updated: Apnimed raises $192M in IPO for potential 2027 sleep apnea drug launch
6. Karyopharm shares crater on second Phase 3 flop for Xpovio in endometrial cancer
7.
peer review
Ionis' top scientist Frank Bennett to retire; Recursion selects its first AI chief
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Kevin Miller
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AbbVie says the arrival of Icotyde from rival J&J hasn't hurt sales of Skyrizi, which rose 24% last quarter. As Nicole DeFeudis writes, AbbVie execs see plenty of headroom in the market to treat plaque psoriasis.

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Kevin Miller
Deputy Editor, Endpoints News
1
by Nicole DeFeudis

If Ab­b­Vie ex­ec­u­tives are both­ered by grow­ing threats to their im­munol­o­gy pow­er­house, they aren't let­ting on.

Ear­li­er this year, an­a­lysts were pon­der­inghow the com­pa­ny’s...

Read the full story
Endpoints 11 - Reserve Your Spot - Save $100 with our Early Bird rate
One night, one room: the founders, scientists and investors behind the Endpoints 11, together in Boston this September. Reserve your spot now and save with the early bird rate.
2
by Max Bayer

Mod­er­na will need an­oth­er norovirus sea­son to ad­e­quate­ly test the ef­fi­ca­cy of its vac­cine, say­ing that it is stand­ing up an ad­di­tion­al tri­al group so...

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3
by Zachary Brennan

HH­S' Health Re­sources and Ser­vices Ad­min­is­tra­tion un­veiled de­tails of a re­vised 340B re­bate pi­lot, which will let some drug man­u­fac­tur­ers de­ny re­bates for a small...

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4
by Elizabeth Cairns

An an­ti-in­flam­ma­to­ry drug from No­vo Nordisk un­ex­pect­ed­ly failed in a Phase 3 study that aimed to prove a link be­tween car­dio­vas­cu­lar in­flam­ma­tion and heart dis­ease...

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Kevin Lind, Apnimed CEO
5
by Kyle LaHucik

In the city that nev­er sleeps, a sleep ap­nea drug de­vel­op­er has se­cured a $192 mil­lion IPO af­ter more than three years of eye­ing a...

Read the full story