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top stories
1. Deaths in Novartis CAR-T trial force a reckoning over acceptable risk in autoimmune disease
2. Three deaths in CAR-T trials prompt halt by Novartis; Bristol Myers programs also paused
3. ARPA-H awards $125M for manufacturing custom RNA therapies on demand
4. Novartis' drug delivery deal with Alteogen; More worker cuts at Cellares
5. Three takeaways from the latest White House drug pricing event
6. Trump announces nine new drug pricing deals, this time with midsize biotechs
Anna Brown
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Following patient deaths in Novartis’ CAR-T program and Bristol Myers’ decision to pause its own studies, there are many unknowns about what may have lead to these issues. Some are pointing to their speedy manufacturing approach as potentially relevant. Feel free to reach out if you have any tips or leads.

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Anna Brown
Biopharma Breaking News Reporter, Endpoints News
1
by Nicole DeFeudis

Many re­searchers be­lieve can­cer cell ther­a­pies called CAR-Ts could shift the treat­ment par­a­digm for pa­tients with au­toim­mune dis­ease. But three re­cent­ly dis­closed deaths in No­var­tis’...

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2
by Nicole DeFeudis

Three pa­tients died in No­var­tis tri­als of its CD19-di­rect­ed CAR-T treat­ment fol­low­ing a dan­ger­ous im­mune sys­tem re­sponse, and a sim­i­lar ther­a­py from Bris­tol My­ers Squibb...

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3
by Ryan Cross

The dream of mak­ing per­son­al­ized ge­net­ic med­i­cines at a mo­ment’s no­tice just got a ma­jor in­fu­sion of fund­ing from the fed­er­al gov­ern­ment.

Five groups were...

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4
by Anna Brown

Plus, news about Novone­sis, As­pen, Fortrea and North­way.

Al­teogen and No­var­tis make a deal: The Swiss phar­ma is li­cens­ingAl­teogen’s hyaluronidase en­zyme, called ALT-B4, which...

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Company executives joined President Donald Trump and top health officials at a drug pricing event on Monday. (Credit: AP Photo/Jacquelyn Martin)
5
by Max Bayer

Pres­i­dent Don­ald Trump an­nounced vol­un­tary drug pric­ing deals with nine new com­pa­nies on Mon­day, for the first time veer­ing out­side of the orig­i­nal crop of...

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6
by Max Bayer

Nine new com­pa­nies have an­nounced vol­un­tary drug pric­ing deals with the White House, look­ing to avoid in­dus­try tar­iffs and in­clu­sion in two CMS pi­lot pro­grams...

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