A review published in PET Clinics found the number of tasks to which large language models have been applied in nuclear medicine increased from 41 to 434 since 2023, with most models being used for information processing. "LLMs represent a transformative evolution from traditional [natural language processing] approaches in nuclear medicine, offering unprecedented capabilities that extend far beyond the rule-based and statistical methods previously employed in the field," researchers wrote.

A systematic review and meta-analysis published in The Journal of Nuclear Medicine found that PET/CT imaging with 18F-PSMA-1007 is effective in the primary staging of prostate carcinoma. The review, which included 19 studies, found that the imaging technique offers high sensitivity and specificity for T, N, and M staging when compared with histopathology.

Researchers have developed a theranostic agent using copper-64 and copper-67 to target solid tumors. The agent, 2,2'-(1,2,4-oxadiazole-3,5-diyl)di aniline, was radiolabeled and evaluated for stability and biodistribution, showing significant tumor uptake in mice and potential interactions with EGFR and VEGFR2, according to the study in Scientific Reports.

A study presented at the annual meeting of the European Society of Medical Oncology found that 177Lu-PSMA-617 is effective and safe for patients 80 and older with metastatic castration-resistant prostate cancer. The retrospective study found progression-free survival of 7.3 months and overall survival of 13.5 months with the treatment, outcomes that were comparable to those of younger patients in previous trials.

Stakeholders are seeking clarifications in the FDA's draft guidance on radiopharmaceutical dosing for cancer treatment, with some requesting alignment with international standards. Eli Lilly and AstraZeneca also are pushing for greater flexibility in the guidance on radiopharmaceutical dosing, particularly in the area of dose escalation.

Around 60% of US adults said they are "extremely" or "very" concerned about rising health care costs next year, according to an AP-NORC poll, with 40% worried about their ability to pay for care or medication. The poll found that 80% of respondents consider health care a top personal issue.

Sen. Rand Paul, R-Ky., proposed forming a bipartisan commission to address expiring Affordable Care Act subsidies, which are the central issue in the ongoing government shutdown. Paul suggested that the government could reopen for a month while the commission works on solutions.

HHS and the FDA are targeting potentially misleading direct-to-consumer drug advertising, requiring full safety warnings and issuing cease-and-desist letters to some companies. Legal challenges are likely, as similar efforts have faced First Amendment issues in the past.