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Biopharma exit outlook brightens; Our new indexes for evergreen funds; Q2 Private Capital Indexes...
November 8, 2025   |   Read online   |   Manage your subscription
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VC, PE and M&A
Presented by the U.S. National Science Foundation
Private market returns: Our Private Capital Indexes track returns across active, closed-end funds, drawing on data representing more than $4 trillion in net asset value. View the Q2 report here.

Speaking of indexes: Morningstar and PitchBook announced the upcoming launch of indexes designed to measure the performance of evergreen funds. Learn more here.

Medtech's new growth wave: AI is at the forefront of advancements in the industry. Smart implants, wearables and surgical navigation are translating AI innovation into tangible, device-level applications. Read our report.

Tune in: Join us Wednesday for our quarterly Venture Monitor webinar. Register here.
 
A message from the U.S. National Science Foundation  
Deep-tech startups get their start with NSF
 
The U.S. National Science Foundation invests in the future today. America’s Seed Fund, powered by NSF, provides up to $2 million in non-dilutive capital to early-stage startups commercializing transformative research in AI, robotics, quantum, biotech, and more.

NSF derisks these deep technology ventures, positioning them for follow-on private capital. In 2024 alone, 255 startups received their first round of funding from NSF. Most had under 10 employees, were newly formed, and are now working to bring their innovations to the market.

NSF funding gets these high-potential startups ready for growth. From 2016 to 2024, the startups funded by NSF saw 300 successful exits and more than $20 billion in follow-on private capital.

Explore the next generation of science-backed startups at seedfund.nsf.gov/next
 
LPs still focused on distributions, but VC continues to disappoint
A depressed exit environment for VC has continued to frustrate LPs, as the 8.1% distribution yield over the past 12 months continues the trend of historically below-average VC distributions. Only following the great financial crisis and the dot-com bust were VC distributions so measly. In the drought of capital being returned, LPs have been reluctant to commit to new VC funds and end up overallocated to the strategy.

PE has been a bright spot, climbing out of its recent lows to a 23.8% distribution yield on beginning NAV over the past year. This has not cleared out the backlog of holdings, however, as 35% of PE NAV is in assets held for seven or more years, up from 27% in 2021.

 
IRRs remain subdued versus the long term for most strategies—though these include both realized and unrealized results. With more assets remaining unrealized for longer, the returns have more reliance on NAV estimations rather than crystallized profits.

Real assets were the stand-out performer over the past year, with its one-year result of 9.6% outperforming its 10-year horizon IRR of 7.7%. Every other strategy posted a one-year result that was less attractive than its long-run performance.

For more data on fund performance as well as a spotlight on whether private markets are worth it in a total portfolio context, please reference the latest Global Fund Performance Report.
 
Best,

Hilary Wiek, CFA, CAIA
Senior Strategist
Biopharma downturn persists, but signs of a recovery emerge
VC funding for biopharma continued its extended downturn in Q3, capturing just 5.6% of total venture dollars deployed, compared to a five-year quarterly average of 8.2%.

Early-stage startups have been hit hardest, with seed rounds falling to a record-low 14% of total biopharma deals YTD. This trend reflects the muted exit environment that has characterized the sector over the last two years.

With just 26 public listings in 2025, the year is on pace to fall well below the annual average of 84 since 2020. Limited exit liquidity has fueled a risk-off sentiment, with investors prioritizing de-risked, clinical-stage assets or moving away from the sector altogether to pursue faster growth opportunities in other tech verticals.

Despite the weak quarter, signs of a recovery are emerging. After several consecutive quarters of decline, deal counts have begun to stabilize, up 3.2% on a TTM basis and now on pace to surpass 2024's multi-year low of 1,080.
 
Source: PitchBook • Geography: Global • As of June 30, 2025
More importantly, exit outlooks are beginning to brighten. Public biotech equities are outperforming market indexes as US policy uncertainty clears and big pharma ramps up M&A activity—often at sizable valuation premiums—ahead of major patent expirations.

Stronger public markets and rising M&A appetite point to a strengthening exit environment for VC-backed startups. MapLight Therapeutics' successful IPO in October and Evommune's planned listing underscore growing positive sentiment. The pace of recovery will depend on these tailwinds continuing to clear the backlog of mature startups—delivering the exit liquidity needed to reignite fundraising and early-stage deal activity. For more data and analysis on the biopharma landscape, check out our latest research on the segment.
 
Best,

Ben Riccio
Analyst, Industry & Technology Research
 
Thematic Research  

Tracking AI Venture Activity in APAC

AI and machine learning startups in Asia-Pacific are attracting a growing share of VC funding, even as overall dealmaking remains subdued.

Total deal value in the sector rose 18.6% year-over-year in 2024, though there has been a slight pullback in 2025 as trade uncertainty has clouded APAC markets.
 

Rising development costs for large models in the US have pushed global investors to the region, where strong hardware supply chains and lower costs offer a more efficient route to scale.

Despite the growth, APAC's fundraising and dealmaking environment continues to reflect broader liquidity constraints. In turn, investors are expected to emphasize capital efficiency, clearer revenue visibility and differentiated intellectual property.

As a result, AI dealmaking in APAC will likely expand at a measured pace: less explosive than the US surge, but more grounded in commercial validation and enterprise adoption. Read the report
 
Industry & Tech Research  

Q3 Food & Beverage CPG

Q3 2025 marked a notable shift in food & beverage consumer packaged goods PE activity, characterized by fewer but larger deals and heightened selectivity among investors.

Deal counts dropped 20% quarter-over-quarter, but capital focused on higher-quality, category-leading assets.

Leading the way were GLP-1s and wellness trends--including functional beverages, vitamins & supplements and protein-enhanced foods. The two factors in tandem drove shake-ups in consumer demand and investor interest.

Expect activity to rebound in 2026 as valuation gaps narrow and investors pursue roll-up plays in packaging, ingredients and sustainability-focused brands in an evolving, health-conscious market.

Read the report
 
Webinars & Events  
Nov. 13: PitchBook is the supporting partner of the inaugural Singapore CVC Summit. Ansel Tan, our APAC director of research, will give a presentation titled "Data Behind the Deals: APAC Corporate Venture." Register here.

Nov. 19: In our Q4 EU Leveraged Finance Analysis & Outlook webinar, PitchBook LCD journalists and researchers will talk about where the private credit markets in Europe will take us during the rest of 2025 and beyond. Register here
 
In the News  

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