FPCOS was recently renamed polyendocrine metabolic ovarian syndrome (PMOS), reflecting what specialists have long understood, that the condition reaches far beyond the ovaries into hormones, metabolism, and mood.
A 2026 double-blind RCT gave 66 overweight or obese women with PCOS either licorice extract or a placebo, both alongside a low-calorie diet, for eight weeks.
The licorice group saw significantly greater improvements in follicle-stimulating hormone (FSH), luteinizing hormone to follicle-stimulating hormone (LH/FSH) ratio, and testosterone levels, along with better sleep quality, lower depression scores, and improved appetite regulation compared to placebo.
Dr. Ruscio's take: What stands out here is the range of outcomes from one intervention: hormones, sleep, and mood all moved together. That tracks with how PMOS often presents, so it makes sense treatment would need to work the same way.
If you're looking for a supplement that contains licorice extract like the one used in this research, our Progest Harmony is formulated to support healthy hormone balance.