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​NEW Premium Notes​

​Genetic Engineering Will Change the World Forever | Cremieux Recueil with Pablo Antonio​

  • This wide-spanning conversation — with some compelling back and forth debate on ethics — covers many existential topics on humanity, society, and politics. Is GDP still a good metric? Where is embryo selection technology heading and what are ethical dilemmas associated with it? Is there an argument for gene editing being a moral necessity? Can we live forever and is that something noble to strive for? Does our meritocracy need critical maintenance? Is space travel going to require a change to the human anatomy? And more, if you can believe it

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​Peptides: Separating Scientific Promise from Marketing Hype | the Drive with Peter Attia (#403)​

  • Peptides are everywhere right now, but how much of the hype is actually backed by evidence? In this episode, Peter Attia breaks down what peptides really are, how to evaluate the science behind them, and why a powerful story, a doctor’s prescription or an impressive testimonial does not automatically mean a peptide works​

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​Phil Knight: Founder of Nike | Founders Podcast with David Senra (#418)​

  • Got a crazy idea? “Just do it!” While this iconic slogan was formulated in Nike’s marketing department, it perfectly captures how Phil Knight started running toward his crazy idea at full speed, as he explains in Shoe Dog: A Memoir by the Creator of Nike. His story is an entrepreneurial masterclass in what can happen when you lace up your shoes and never stop until you reach the finish line

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Top Premium Takeaways Of The Week


​Genetic Engineering Will Change the World Forever | Cremieux Recueil with Pablo Antonio​

Everything good is correlated with high IQ

  • Creativity, communication, problem solving, etc

“Health positive manifold” = the smarter you are the more physically and mentally healthy you are

  • “Not always to a huge degree, but to at least some degree”
  • Smarter = better job = more money = more resources for health?

“Gene editing is a moral XXXX”

  • Gene editing and gene therapy are just the next tier of XXXX​
  • ​XXXX protects us from bad outcomes, so why is this any different?
  • Especially if the XXXX to do so approaches zero

Targeted edits to a gene can mimic taking a XXXX for life

  • Gene therapies are permanent one-time XXXX​
  • “We can save so many lives without having to worry about XXXX”

“We’re very close to just eradicating XXXX with gene therapies”

  • Example: Lipoprotein(a) or Lp(a) deposits on the walls of your arteries and causes heart disease at very high rates. There are currently no drugs for it, but there are XXXX in trials right now

There’s no reason to worry about side effects when editing genes for XXXX​

  • Example: A healthy person has a genetic predisposition to low cholesterol. Because of this, they have better overall health and a lower risk of heart attack. So, given the evidence, why would we assume editing a dysfunctional cholesterol gene to be lower could have any effect other than XXXX? The gene simply does what it’s coded to do

The USA and China are both failing at XXXX​

  • The Guokao test in China accurately identifies the smartest people, but China XXXX them
    • The smart people end up working on XXXX things rather than innovation in the private markets
  • America, alternatively, doesn’t send any smart people to work in XXXX​
    • The XXXX doesn’t pay well and has eternally growing regulations that deter innovators

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​Peptides: Separating Scientific Promise from Marketing Hype | the Drive with Peter Attia (#403)​

Use this same framework for any drug (BPC 157 fails every part of the framework):

  • (1) Is there a viable mechanism of action?
    • What is the molecular target
    • What changes downstream
    • Why would that produce the clinical effect being claimed
  • “Without that chain, a claim like it boosts energy or supports immunity or reduces inflammation can mean almost anything and almost certainly XXXX”
  • A real mechanism also shows you how a product could XXXX​
    • It may not reach the relevant XXXX​
    • It may require an unsafe XXXX​
    • It may move a biomarker without changing XXXX​
  • If a compound has no XXXX, that should be an early red flag
  • (2) Does it improve meaningful outcomes in XXXX​
  • (3) Do we understand dosing, XXXX, short term risk, long term risk and what you need to XXXX?
  • (4) Judge XXXX in context
    • A serious risk can be XXXX for a lethal disease
    • The same risk may make no sense for a XXXX improvement in wellness or recovery
  • (5) Is there a better characterized way to get XXXX?

Peptides create a perfect setting for XXXX to influence results…

  • Social media testimonials make them feel XXXX​
  • A clinician or peptide clinic adds XXXX​
  • Paying a lot of money raises XXXX​
  • Injections feel XXXX and serious
“XXXX are how you separate the drug from the drama that surrounds it”

The biggest wellness claims often sit in the hardest areas to XXXX​

  • ​XXXX is difficult because of the blood brain barrier
  • ​XXXX is biologically complex
  • Broad promises of XXXX and XXXX are harder to test than treating a specific disease

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​Phil Knight: Founder of Nike | Founders Podcast with David Senra (#418)​

Not wanting to lose can be more powerful than wanting to win

  • Phil attended undergrad at the University of Oregon, graduated with a master’s degree from Stanford, and spent a year in the Army. But then, he found himself back at home in his childhood bedroom…
  • Phil didn’t know what success would look like for him — like his friends with budding careers — but all he knew was that he needed to be successful to live a meaningful life
  • “Like it or not, life is a game. Whoever refuses to play, gets left on the sidelines. And I didn’t want that.”

Your first employees need to be as XXXX as you are

  • Jeff Johnson didn’t only help Phil sell shoes, but he wanted to expand his XXXX, he wanted to try new marketing strategies, and he craved XXXX — he wrote to Phil from California unanswered almost every day