This year’s Thanksgiving feast might look a little different around your dinner table, thanks to GLP-1s such as Ozempic. The drug triggers weight loss by curbing users’ appetites, and it’s made this holiday, marked by second helpings and elastic waistbands, a tricky one for GLP-1 users who might face digestive issues if they eat too much. From smaller portion sizes, recipe tweaks and potentially awkward social politics, get ready for turkey day to be a bit more fraught this time.

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